The differentiation of mammalian neurons during development is a highly complex process involving regulation and coordination of gene expression at multiple steps. The P19 mouse embryonal carcinoma cell line is a suitable model system with which to analyze regulation of neuronal differentiation. These multipotential cells can be maintained and propagated in tissue culture in an undifferentiated state. Exposure of aggregated P19 cells to retinoic acid results in the differentiation of cells with many fundamental phenotypes of mammalian neurons. Undifferentiated P19 cells (...) are amenable to genetic manipulations such as transfection and establishment of stable clonal cell lines expressing introduced genes. Proteins that play a key role in the neuronal differentiation of P19 cells are beginning to be identified. These include retinoic acid receptors, the epidermal growth factor receptor and the transcription factors Oct‐3 and Brn‐2. The biological and technical advantages of this system should facilitate deeper analysis of the activities of proteins that play a role in neuronal differentiation. (shrink)

In a series of lectures from 1804–05, Johann Gottlieb Fichte sets out a conception of enlightenment whose basic structure is, I argue, to some extent reproduced in two more famous accounts of enlightenment found in post-Kantian German philosophy: Hegel’s account of the Enlightenment’s struggle with faith in his Phenomenology of Spirit and the conception of enlightenment rationality presented in Horkheimer and Adorno’s Dialectic of Enlightenment. The narrative I offer serves to highlight, moreover, the critical role played by the notion (...) of an unconditional good in Fichte’s and Hegel’s critiques of enlightenment. The lack of an explicit appeal to, and account of, this notion in Horkheimer and Adorno’s critique of enlightenment will be shown to raise questions concerning how successful their critique of enlightenment can really be thought to be. (shrink)

Sense and Sensitivity explores the semantics and pragmatics of focus in natural language discourse, advancing a new account of focus sensitivity which posits a three-way distinction between different effects of focus. Makes a valuable contribution to the ongoing research in the field of focus sensitivity Discusses the features of QFC, an original theory of focus implying a new typology of focus-sensitive expressions Presents novel cross-linguistic data on focus and focus sensitivity Concludes with a case study of exclusives (like “only”), arguing (...) that the entire existing literature (reviewed in detail) has missed crucial generalizations, and that the focus sensitivity of these expressions must be understood in terms of their meaning and discourse function. (shrink)

In this essay, David Waddington and Noah Weeth Feinstein explore how Dewey's conception of science can help us rethink the way science is done in schools. The authors begin by contrasting a view of science that is implicitly accepted by many scientists and science educators — science as a search for truth — with Dewey's instrumentalist, technological, and nonrealist conception of science. After demonstrating that the search-for-truth conception is closely linked to some ongoing difficulties with science curricula that students (...) find particularly alienating, they then analyze some of the educational opportunities that Dewey's vision opens up. Ultimately, Waddington and Weeth Feinstein argue that Dewey offers a humble and humanistic vision of science and science education practice that captures the power of science by connecting it clearly to everyday human activities and challenges. (shrink)

An introduction to category theory as a rigorous, flexible, and coherent modeling language that can be used across the sciences. Category theory was invented in the 1940s to unify and synthesize different areas in mathematics, and it has proven remarkably successful in enabling powerful communication between disparate fields and subfields within mathematics. This book shows that category theory can be useful outside of mathematics as a rigorous, flexible, and coherent modeling language throughout the sciences. Information is inherently dynamic; the same (...) ideas can be organized and reorganized in countless ways, and the ability to translate between such organizational structures is becoming increasingly important in the sciences. Category theory offers a unifying framework for information modeling that can facilitate the translation of knowledge between disciplines. Written in an engaging and straightforward style, and assuming little background in mathematics, the book is rigorous but accessible to non-mathematicians. Using databases as an entry to category theory, it begins with sets and functions, then introduces the reader to notions that are fundamental in mathematics: monoids, groups, orders, and graphs—categories in disguise. After explaining the “big three” concepts of category theory—categories, functors, and natural transformations—the book covers other topics, including limits, colimits, functor categories, sheaves, monads, and operads. The book explains category theory by examples and exercises rather than focusing on theorems and proofs. It includes more than 300 exercises, with solutions. Category Theory for the Sciences is intended to create a bridge between the vast array of mathematical concepts used by mathematicians and the models and frameworks of such scientific disciplines as computation, neuroscience, and physics. (shrink)

In this paper the Centering model of anaphoraresolution and discourse coherence(Grosz et al. 1983, 1995)is reformulated in terms of Optimality Theory (OT)(Prince and Smolensky 1993). One version of the reformulated modelis proven to be descriptively equivalent to an earlier algorithmicstatement of Centering due to Brennan, Friedman and Pollard(1987). However, the new model is stated declaratively, and makesclearer the status of the various constraints used in the theory. Inthe second part of the paper, the model is extended, demonstratingthe advantages of the (...) OT reformulation, and capturing formallyideas originally described by Grosz, Joshi and Weinstein. Three newapplications of the extended OT Centering model are described:generation of linguistic forms from meanings, the evaluation andoptimization of extended texts, and the interpretation of accentedpronouns. (shrink)

We discuss presupposition, the phenomenon whereby speakers mark linguistically the information that is presupposed or taken for granted, rather than being part of the main propositional content of a speech act. Expressions and constructions carrying presuppositions are called “presupposition triggers”, forming a large class including definites and factive verbs. The article first introduces the range of triggers, the basic properties of presuppositions such as projection and cancellability, and the diagnostic tests used to identify them. The reader is then introducedto major (...) models of presupposition from the last 50 years, separated into three classes: Frege-Strawson derived semantic models, pragmaticmodels such as that offered by Stalnaker, and dynamic models. Finallywe discuss some of the main current issues in presupposition theory. These involve accommodation, which occurs when a hearer's knowledge state is adjusted to meet the speaker's presuppositions; presupposition failure, which occurs when a presupposition is false; the interaction between presuppositions and attitudes; and the triggering problem, i.e., the problem of explaining why presuppositions occur in the first place. (shrink)

Expression of transgenes in mice, when examined with assays that can distinguish individual cells, is often found to be heterocellular, or variegated. Line‐to‐line variations in expression of a transgene may be due largely to differences in the proportion of cells in which it is expressed. Variegated silencing by centromeric heterochromatin is well described, but other factors may also affect transgene silencing in mice. Tandem arrays of transgenes themselves form heterochromatin, and some cell lineages may tend to silence transgenes because of (...) extensive facultative heterochromatin in their nuclei. The cis‐acting transcriptional control elements within a transgene inhibit silencing, and strainspecific differences in chromatin proteins may strongly influence the extent of variegation. The accessibility of multiple differentiated cell lineages in mice suggests that they may provide a tool for dissecting the role of chromatin‐mediated silencing in cell differentiation and tissue‐specific gene expression. (shrink)

Critics like Leonard Waks argue that video games are, at best, a dubious substitute for the rich classroom experiences that John Dewey wished to create and that, at worst, they are profoundly miseducative. Using the example of Fate of the World, a climate change simulation game, David Waddington addresses these concerns through a careful demonstration of how video games can recapture some of the lost potential of Dewey's original program of education through occupations. Not only do simulation games realize (...) most of the original goals of education through occupations, but they also solve some of the serious practical problems that Dewey's curriculum generated. Waddington concludes the essay with an analysis of Waks's critiques and some cautionary notes about why it is important to be temperate in our endorsement of educational video gaming. (shrink)

One of the interesting aspects of Dewey’s early educational thought is his apparent hostility toward children’s imaginative pursuits, yet the question of why this antipathy exists remains unanswered. As will become clear, Dewey’s hostility towards imaginative activities stemmed from a broad variety of concerns. In some of his earliest work, Dewey adopted a set of anti-Romantic criticisms and used these concerns to attack what one might call “runaway” imaginative and emotional tendencies. Then, in his early educational writings, these earlier concerns (...) were augmented by several other factors, including problematic trends in progressive education, new developments in psychology, and Dewey’s own educational aims. This analysis explores the roots of these criticisms, and explains how they culminate in the stance on the imagination that Dewey eventually outlined in the early educational writings. Notably, these findings have some important implications for certain prominent contemporary critics of progressivism. (shrink)

The rise in vaccine hesitancy in high-income countries has led some to recommend that certain vaccinations be made compulsory in states where they are currently voluntary. In contrast, I contend that legal coercion is generally inappropriate to address the complex social and psychological phenomenon of vaccine anxieties.

In January 2019 the Faculty of Philosophy of the Lomonosov Moscow State University held the round table “Problems of Consciousness: Research Opportunities.” It was dedicated to problems of interdisciplinary studies of consciousness. Many famous Russian specialists whose academic interests include consciousness, brain and mind took part in this event: K.V. Anokhin, D.I. Dubrovsky, T.V. Chernigovskaya, M.A. Piradov, A.A. Potapov, V.Y. Sergin, V.V. Vasil’ev, Z.A. Zorina and others. At the round table, the following problems were discussed: the specificity of consciousness problem, (...) its relevance in various academic disciplines, contemporary research possibilities for consciousness studies to solve the problems that specialists actually face. Much attention was paid to the problems of neurobiology, empirical research of consciousness. Nonetheless, participants showed in their speeches that the problem of consciousness is also a philosophical problem. Hence it requires thoughtful consideration of philosophers. Participants decided that to progress in solving this problem researches from various disciplines have to cooperate. (shrink)

The Gold and the Dross: Althusser for Educators is an introduction to the philosophy of Louis Althusser for educators, activists, and those who are new to theory in general.